| 2022-11-02 16:30:4002/11/2022 | Santiago Wanderers  | 2 - 0 |  Deportes Santa Cruz | 16:30:4016:30 | N/A |
| 2022-10-24 18:00:5624/10/2022 | Deportes Santa Cruz | 2 - 1 |  Deportes Melipilla | 18:00:5618:00 | N/A |
| 2022-10-16 17:30:1416/10/2022 | San Luis de Quillota  | 0 - 0 | Deportes Santa Cruz | 17:30:1417:30 | N/A |
| 2022-10-10 20:00:3310/10/2022 | Deportes Santa Cruz | 4 - 0 |  Unión San Felipe | 20:00:3320:00 | N/A |
| 2022-10-03 15:30:5903/10/2022 | Deportes Recoleta  | 2 - 1 | Deportes Santa Cruz | 15:30:5915:30 | N/A |
| 2022-09-25 20:30:0625/09/2022 | Deportes Santa Cruz | 0 - 2 |  Deportes Puerto Montt | 20:30:0620:30 | N/A |
| 2022-08-08 12:30:4308/08/2022 | A.C. Barnechea  | 2 - 0 | Deportes Santa Cruz | 12:30:4312:30 | N/A |
| 2022-07-31 20:30:2231/07/2022 | Deportes Santa Cruz | 1 - 1 |  Cobreloa | 20:30:2220:30 | N/A |
| 2022-07-26 18:00:3126/07/2022 | Deportes Santa Cruz | 2 - 0 |  Arturo Fernández Vial | 18:00:3118:00 | N/A |
| 2022-07-16 11:00:4716/07/2022 | Magallanes  | 0 - 0 | Deportes Santa Cruz | 11:00:4711:00 | N/A |
| 2022-07-08 18:00:1708/07/2022 | Deportes Santa Cruz | 1 - 0 |  Santiago Morning | 18:00:1718:00 | N/A |
| 2022-07-02 12:30:3802/07/2022 | Deportes Temuco  | 1 - 1 | Deportes Santa Cruz | 12:30:3812:30 | N/A |
| 2022-06-02 15:00:4202/06/2022 | Cobreloa | 1 - 0 | Deportes Santa Cruz | 15:00:4215:00 | N/A |
| 2022-05-27 18:00:4827/05/2022 | Deportes Santa Cruz | 2 - 0 | Santiago Wanderers | 18:00:4818:00 | N/A |
| 2022-05-22 17:30:4922/05/2022 | Deportes Melipilla | 1 - 0 | Deportes Santa Cruz | 17:30:4917:30 | N/A |
| 2022-05-17 20:30:3717/05/2022 | Deportes Santa Cruz | 2 - 0 | San Luis de Quillota | 20:30:3720:30 | N/A |
| 2022-04-30 14:30:5830/04/2022 | Deportes Puerto Montt | 3 - 0 | Deportes Santa Cruz | 14:30:5814:30 | N/A |
| 2022-04-25 20:30:5325/04/2022 | Deportes Santa Cruz | 2 - 2 |  Deportes Copiapó | 20:30:5320:30 | N/A |
| 2022-04-20 20:30:3120/04/2022 | Rangers  | 2 - 1 | Deportes Santa Cruz | 20:30:3120:30 | N/A |
| 2022-04-11 18:00:1911/04/2022 | Deportes Santa Cruz | 0 - 0 |  Universidad de Concepción | 18:00:1918:00 | N/A |
| 2022-04-03 12:30:4703/04/2022 | Deportes Iquique  | 2 - 2 | Deportes Santa Cruz | 12:30:4712:30 | N/A |
| 2022-03-23 20:30:5323/03/2022 | Deportes Santa Cruz | 1 - 1 | A.C. Barnechea | 20:30:5320:30 | N/A |
| 2022-03-07 18:30:0707/03/2022 | Arturo Fernández Vial | 1 - 0 | Deportes Santa Cruz | 18:30:0718:30 | N/A |
| 2022-03-01 18:00:1701/03/2022 | Deportes Santa Cruz | 1 - 2 | Magallanes | 18:00:1718:00 | N/A |
| 2022-02-22 18:00:1722/02/2022 | Santiago Morning | 2 - 1 | Deportes Santa Cruz | 18:00:1718:00 | N/A |
| 2021-11-13 18:00:0613/11/2021 | San Marcos de Arica  | 0 - 0 | Deportes Santa Cruz | 18:00:0618:00 | N/A |
| 2021-11-06 20:30:0406/11/2021 | Deportes Santa Cruz | 2 - 2 | Cobreloa | 20:30:0420:30 | N/A |
| 2021-11-01 18:00:5501/11/2021 | Deportes Santa Cruz | 2 - 0 | A.C. Barnechea | 18:00:5518:00 | N/A |
| 2021-10-23 15:30:4423/10/2021 | Magallanes | 1 - 1 | Deportes Santa Cruz | 15:30:4415:30 | N/A |
| 2021-10-19 16:00:5919/10/2021 | Deportes Santa Cruz | 1 - 0 | Rangers | 16:00:5916:00 | N/A |
| 2021-09-23 21:00:1123/09/2021 | Coquimbo Unido  | 0 - 0 | Deportes Santa Cruz | 21:00:1121:00 | N/A |
| 2021-09-14 16:30:5914/09/2021 | Deportes Santa Cruz | 1 - 0 | Deportes Temuco | 16:30:5916:30 | N/A |
| 2021-09-05 12:00:4105/09/2021 | Deportes Puerto Montt | 2 - 2 | Deportes Santa Cruz | 12:00:4112:00 | N/A |
| 2021-08-31 20:00:4731/08/2021 | Deportes Santa Cruz | 1 - 1 | Santiago Morning | 20:00:4720:00 | N/A |
| 2021-08-27 18:30:1627/08/2021 | Universidad de Concepción | 0 - 1 | Deportes Santa Cruz | 18:30:1618:30 | N/A |
| 2021-08-22 15:00:3422/08/2021 | Arturo Fernández Vial | 2 - 1 | Deportes Santa Cruz | 15:00:3415:00 | N/A |
| 2021-08-15 11:30:1915/08/2021 | Deportes Santa Cruz | 2 - 0 | San Marcos de Arica | 11:30:1911:30 | N/A |
| 2021-08-08 11:00:5708/08/2021 | Cobreloa | 0 - 1 | Deportes Santa Cruz | 11:00:5711:00 | N/A |
| 2021-08-03 14:00:4103/08/2021 | A.C. Barnechea | 0 - 0 | Deportes Santa Cruz | 14:00:4114:00 | N/A |
| 2021-07-24 15:00:5224/07/2021 | Deportes Santa Cruz | 2 - 3 | Arturo Fernández Vial | 15:00:5215:00 | N/A |
| 2021-07-21 15:30:2621/07/2021 | Deportes Santa Cruz | 2 - 0 | Magallanes | 15:30:2615:30 | N/A |
| 2021-05-30 12:00:4830/05/2021 | Deportes Santa Cruz | 1 - 3 | Deportes Iquique | 12:00:4812:00 | N/A |
| 2021-05-25 16:00:1725/05/2021 | Unión San Felipe | 1 - 0 | Deportes Santa Cruz | 16:00:1716:00 | N/A |
| 2021-05-10 18:00:2710/05/2021 | Deportes Temuco | 0 - 1 | Deportes Santa Cruz | 18:00:2718:00 | N/A |
| 2021-05-02 20:30:0002/05/2021 | Deportes Santa Cruz | 1 - 0 | Deportes Puerto Montt | 20:30:0020:30 | N/A |
| 2021-04-26 15:30:4126/04/2021 | Santiago Morning | 1 - 3 | Deportes Santa Cruz | 15:30:4115:30 | N/A |
| 2021-04-18 18:00:2818/04/2021 | Deportes Santa Cruz | 2 - 2 | Universidad de Concepción | 18:00:2818:00 | N/A |
Chile
