| 2021-11-13 18:00:0613/11/2021 | San Marcos de Arica  | 0 - 0 |  Deportes Santa Cruz | 18:00:0618:00 | N/A |
| 2021-11-06 20:30:0406/11/2021 | Deportes Santa Cruz | 2 - 2 |  Cobreloa | 20:30:0420:30 | N/A |
| 2021-11-01 18:00:5501/11/2021 | Deportes Santa Cruz | 2 - 0 |  A.C. Barnechea | 18:00:5518:00 | N/A |
| 2021-10-23 15:30:4423/10/2021 | Magallanes  | 1 - 1 | Deportes Santa Cruz | 15:30:4415:30 | N/A |
| 2021-10-19 16:00:5919/10/2021 | Deportes Santa Cruz | 1 - 0 |  Rangers | 16:00:5916:00 | N/A |
| 2021-10-12 18:00:5512/10/2021 | San Luis de Quillota  | 0 - 0 | Deportes Santa Cruz | 18:00:5518:00 | N/A |
| 2021-10-08 18:30:3608/10/2021 | Deportes Santa Cruz | 1 - 2 |  Deportes Copiapó | 18:30:3618:30 | N/A |
| 2021-10-03 12:30:4403/10/2021 | Deportes Iquique  | 6 - 1 | Deportes Santa Cruz | 12:30:4412:30 | N/A |
| 2021-09-28 18:30:5028/09/2021 | Deportes Santa Cruz | 0 - 1 |  Unión San Felipe | 18:30:5018:30 | N/A |
| 2021-09-23 21:00:1123/09/2021 | Coquimbo Unido  | 0 - 0 | Deportes Santa Cruz | 21:00:1121:00 | N/A |
| 2021-09-14 16:30:5914/09/2021 | Deportes Santa Cruz | 1 - 0 |  Deportes Temuco | 16:30:5916:30 | N/A |
| 2021-09-05 12:00:4105/09/2021 | Deportes Puerto Montt  | 2 - 2 | Deportes Santa Cruz | 12:00:4112:00 | N/A |
| 2021-08-31 20:00:4731/08/2021 | Deportes Santa Cruz | 1 - 1 |  Santiago Morning | 20:00:4720:00 | N/A |
| 2021-08-27 18:30:1627/08/2021 | Universidad de Concepción  | 0 - 1 | Deportes Santa Cruz | 18:30:1618:30 | N/A |
| 2021-08-22 15:00:3422/08/2021 | Arturo Fernández Vial  | 2 - 1 | Deportes Santa Cruz | 15:00:3415:00 | N/A |
| 2021-08-15 11:30:1915/08/2021 | Deportes Santa Cruz | 2 - 0 | San Marcos de Arica | 11:30:1911:30 | N/A |
| 2021-08-08 11:00:5708/08/2021 | Cobreloa | 0 - 1 | Deportes Santa Cruz | 11:00:5711:00 | N/A |
| 2021-08-03 14:00:4103/08/2021 | A.C. Barnechea | 0 - 0 | Deportes Santa Cruz | 14:00:4114:00 | N/A |
| 2021-07-24 15:00:5224/07/2021 | Deportes Santa Cruz | 2 - 3 | Arturo Fernández Vial | 15:00:5215:00 | N/A |
| 2021-07-21 15:30:2621/07/2021 | Deportes Santa Cruz | 2 - 0 | Magallanes | 15:30:2615:30 | N/A |
| 2021-07-15 15:00:1215/07/2021 | Rangers | 1 - 3 | Deportes Santa Cruz | 15:00:1215:00 | N/A |
| 2021-07-11 15:30:2411/07/2021 | Deportes Santa Cruz | 2 - 0 | San Luis de Quillota | 15:30:2415:30 | N/A |
| 2021-04-26 15:30:4126/04/2021 | Santiago Morning | 1 - 3 | Deportes Santa Cruz | 15:30:4115:30 | N/A |
| 2021-01-17 10:00:5017/01/2021 | Deportes Santa Cruz | 3 - 2 |  Deportes Valdivia | 10:00:5010:00 | N/A |
| 2021-01-12 18:00:2812/01/2021 | Magallanes | 2 - 0 | Deportes Santa Cruz | 18:00:2818:00 | N/A |
| 2020-12-27 21:30:4227/12/2020 | Deportes Santa Cruz | 1 - 3 |  Ñublense | 21:30:4221:30 | N/A |
| 2020-12-23 20:30:0523/12/2020 | Deportes Melipilla  | 0 - 0 | Deportes Santa Cruz | 20:30:0520:30 | N/A |
| 2020-12-14 20:15:3514/12/2020 | Rangers | 4 - 1 | Deportes Santa Cruz | 20:15:3520:15 | N/A |
| 2020-11-30 10:30:4030/11/2020 | Deportes Copiapó | 2 - 0 | Deportes Santa Cruz | 10:30:4010:30 | N/A |
| 2020-11-24 18:00:2124/11/2020 | Deportes Santa Cruz | 0 - 2 | San Marcos de Arica | 18:00:2118:00 | N/A |
| 2020-11-20 18:00:0320/11/2020 | Santiago Morning | 2 - 1 | Deportes Santa Cruz | 18:00:0318:00 | N/A |
| 2020-10-12 13:30:5412/10/2020 | Deportes Santa Cruz | 1 - 4 | Deportes Copiapó | 13:30:5413:30 | N/A |
| 2020-10-04 19:00:2404/10/2020 | Deportes Santa Cruz | 0 - 3 | Magallanes | 19:00:2419:00 | N/A |
| 2020-09-20 13:30:3420/09/2020 | Deportes Santa Cruz | 0 - 2 | Deportes Temuco | 13:30:3413:30 | N/A |
| 2020-09-14 13:30:1814/09/2020 | Ñublense | 2 - 2 | Deportes Santa Cruz | 13:30:1813:30 | N/A |
| 2020-09-10 13:30:0310/09/2020 | Deportes Santa Cruz | 0 - 1 | Deportes Puerto Montt | 13:30:0313:30 | N/A |
| 2020-09-06 12:00:3706/09/2020 | Cobreloa | 0 - 1 | Deportes Santa Cruz | 12:00:3712:00 | N/A |
| 2020-08-31 15:00:1831/08/2020 | Deportes Santa Cruz | 2 - 4 | Deportes Melipilla | 15:00:1815:00 | N/A |
| 2020-03-01 18:00:2701/03/2020 | Deportes Santa Cruz | 0 - 2 | Rangers | 18:00:2718:00 | N/A |
| 2020-02-23 19:00:4723/02/2020 | Deportes Valdivia | 1 - 0 | Deportes Santa Cruz | 19:00:4719:00 | N/A |
Chile
