| 2021-11-13 15:30:5913/11/2021 | Cobreloa  | 4 - 1 |  Rangers | 15:30:5915:30 | N/A |
| 2021-11-06 20:30:0406/11/2021 | Deportes Santa Cruz  | 2 - 2 | Cobreloa | 20:30:0420:30 | N/A |
| 2021-11-01 20:30:0201/11/2021 | Cobreloa | 0 - 2 |  Deportes Temuco | 20:30:0220:30 | N/A |
| 2021-10-27 20:00:3027/10/2021 | Deportes Puerto Montt  | 0 - 0 | Cobreloa | 20:00:3020:00 | N/A |
| 2021-10-20 19:00:4520/10/2021 | Arturo Fernández Vial  | 3 - 2 | Cobreloa | 19:00:4519:00 | N/A |
| 2021-10-16 15:00:1916/10/2021 | Cobreloa | 2 - 0 |  Deportes Copiapó | 15:00:1915:00 | N/A |
| 2021-10-12 20:30:0112/10/2021 | Deportes Iquique  | 1 - 0 | Cobreloa | 20:30:0120:30 | N/A |
| 2021-10-06 18:00:4206/10/2021 | Cobreloa | 2 - 1 |  Magallanes | 18:00:4218:00 | N/A |
| 2021-10-01 20:00:3201/10/2021 | San Luis de Quillota  | 1 - 0 | Cobreloa | 20:00:3220:00 | N/A |
| 2021-09-26 14:00:0726/09/2021 | Cobreloa | 1 - 2 | Arturo Fernández Vial | 14:00:0714:00 | N/A |
| 2021-09-22 12:00:2122/09/2021 | Santiago Morning  | 2 - 1 | Cobreloa | 12:00:2112:00 | N/A |
| 2021-09-01 20:00:3301/09/2021 | Universidad de Concepción  | 0 - 0 | Cobreloa | 20:00:3320:00 | N/A |
| 2021-08-29 12:00:5829/08/2021 | Cobreloa | - |  San Marcos de Arica | 12:00:5812:00 | N/A |
| 2021-08-24 11:00:5624/08/2021 | A.C. Barnechea  | 1 - 1 | Cobreloa | 11:00:5611:00 | N/A |
| 2021-08-08 11:00:5708/08/2021 | Cobreloa | 0 - 1 | Deportes Santa Cruz | 11:00:5711:00 | N/A |
| 2021-07-31 15:00:4231/07/2021 | Deportes Temuco | 1 - 0 | Cobreloa | 15:00:4215:00 | N/A |
| 2021-07-21 11:00:3921/07/2021 | Cobreloa | 2 - 0 | Deportes Puerto Montt | 11:00:3911:00 | N/A |
| 2021-07-14 18:00:3914/07/2021 | Deportes Copiapó | 0 - 0 | Cobreloa | 18:00:3918:00 | N/A |
| 2021-07-09 15:30:1509/07/2021 | Cobreloa | 3 - 2 | Deportes Iquique | 15:30:1515:30 | N/A |
| 2021-05-30 12:00:3830/05/2021 | Cobreloa | 1 - 0 | San Luis de Quillota | 12:00:3812:00 | N/A |
| 2021-05-18 12:00:2818/05/2021 | Cobreloa | 2 - 2 | Santiago Morning | 12:00:2812:00 | N/A |
| 2021-05-09 20:30:2609/05/2021 | Unión San Felipe  | 0 - 0 | Cobreloa | 20:30:2620:30 | N/A |
| 2021-05-03 18:00:5703/05/2021 | Cobreloa | 1 - 1 |  Coquimbo Unido | 18:00:5718:00 | N/A |
| 2021-04-26 11:00:2026/04/2021 | Cobreloa | 2 - 4 | Universidad de Concepción | 11:00:2011:00 | N/A |
| 2021-04-18 17:00:0418/04/2021 | San Marcos de Arica | 0 - 3 | Cobreloa | 17:00:0417:00 | N/A |
| 2021-04-04 11:00:1104/04/2021 | Cobreloa | 1 - 2 | A.C. Barnechea | 11:00:1111:00 | N/A |
Argentina
