| 2022-11-11 18:00:3311/11/2022 | Unión San Felipe  | 0 - 1 |  Deportes Puerto Montt | 18:00:3318:00 | N/A |
| 2022-11-06 13:00:2006/11/2022 | Deportes Puerto Montt | 2 - 1 | Unión San Felipe | 13:00:2013:00 | N/A |
| 2022-11-01 17:30:5901/11/2022 | Unión San Felipe | 2 - 1 |  Arturo Fernández Vial | 17:30:5917:30 | N/A |
| 2022-10-22 15:00:2522/10/2022 | Deportes Iquique  | 3 - 0 | Unión San Felipe | 15:00:2515:00 | N/A |
| 2022-10-16 20:00:4916/10/2022 | Unión San Felipe | 1 - 0 | Deportes Puerto Montt | 20:00:4920:00 | N/A |
| 2022-10-02 20:30:0502/10/2022 | Unión San Felipe | 1 - 4 |  Magallanes | 20:30:0520:30 | N/A |
| 2022-09-26 17:30:1426/09/2022 | Cobreloa  | 1 - 0 | Unión San Felipe | 17:30:1417:30 | N/A |
| 2022-09-06 20:30:1206/09/2022 | Deportes Temuco  | 1 - 0 | Unión San Felipe | 20:30:1220:30 | N/A |
| 2022-08-30 18:00:3930/08/2022 | Unión San Felipe | 1 - 0 |  Universidad de Concepción | 18:00:3918:00 | N/A |
| 2022-08-23 20:30:2323/08/2022 | San Luis de Quillota  | 2 - 2 | Unión San Felipe | 20:30:2320:30 | N/A |
| 2022-08-15 17:30:2015/08/2022 | Unión San Felipe | 2 - 1 |  A.C. Barnechea | 17:30:2017:30 | N/A |
| 2022-08-09 20:00:2809/08/2022 | Deportes Melipilla  | 1 - 0 | Unión San Felipe | 20:00:2820:00 | N/A |
| 2022-07-25 20:30:5425/07/2022 | Unión San Felipe | 2 - 0 |  Santiago Morning | 20:30:5420:30 | N/A |
| 2022-07-18 18:00:1518/07/2022 | Rangers  | 2 - 1 | Unión San Felipe | 18:00:1518:00 | N/A |
| 2022-07-08 18:00:3008/07/2022 | Unión San Felipe | 3 - 1 |  Deportes Copiapó | 18:00:3018:00 | N/A |
| 2022-07-01 20:30:1501/07/2022 | Deportes Recoleta  | 3 - 3 | Unión San Felipe | 20:30:1520:30 | N/A |
| 2022-06-09 18:00:4409/06/2022 | Santiago Wanderers  | 0 - 1 | Unión San Felipe | 18:00:4418:00 | N/A |
| 2022-06-05 20:30:5005/06/2022 | Unión San Felipe | 0 - 0 | Deportes Recoleta | 20:30:5020:30 | N/A |
| 2022-05-31 18:00:2531/05/2022 | Arturo Fernández Vial | 1 - 1 | Unión San Felipe | 18:00:2518:00 | N/A |
| 2022-05-21 12:30:2621/05/2022 | Unión San Felipe | 2 - 0 | Deportes Iquique | 12:30:2612:30 | N/A |
| 2022-05-16 18:00:5716/05/2022 | Deportes Puerto Montt | 2 - 1 | Unión San Felipe | 18:00:5718:00 | N/A |
| 2022-05-12 18:00:5512/05/2022 | Unión San Felipe | 2 - 1 |  Deportes Santa Cruz | 18:00:5518:00 | N/A |
| 2022-05-08 15:00:2008/05/2022 | Magallanes | 1 - 0 | Unión San Felipe | 15:00:2015:00 | N/A |
| 2022-04-29 18:00:4329/04/2022 | Unión San Felipe | 1 - 1 | Cobreloa | 18:00:4318:00 | N/A |
| 2022-04-15 19:00:0315/04/2022 | Universidad de Concepción | 1 - 3 | Unión San Felipe | 19:00:0319:00 | N/A |
| 2022-04-11 20:30:5211/04/2022 | Unión San Felipe | 2 - 0 | San Luis de Quillota | 20:30:5220:30 | N/A |
| 2022-04-04 15:45:1104/04/2022 | A.C. Barnechea | 0 - 1 | Unión San Felipe | 15:45:1115:45 | N/A |
| 2022-03-23 20:30:0823/03/2022 | Unión San Felipe | 1 - 0 | Deportes Melipilla | 20:30:0820:30 | N/A |
| 2022-03-08 18:00:5808/03/2022 | Santiago Morning | 1 - 1 | Unión San Felipe | 18:00:5818:00 | N/A |
| 2022-03-02 20:30:5802/03/2022 | Unión San Felipe | 1 - 0 | Rangers | 20:30:5820:30 | N/A |
Uruguay
